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Laboratory of Lipoproteins, Immunity and Atherosclerosis  

Lab. Catapano

 

Director
Prof. Alberico Catapano alberico.catapano@unimi.it

Collaborators
Giuseppe Danilo Norata, Assistant Professor danilo.norata@unimi.it
Gianpaolo Tibolla, Research Associate gianpaolo.tibolla@unimi.it
Andrea Baragetti, PhD Student andrea.baragetti@unimi.it
Fabrizia Bonacina, PhD Student fabrizia.bonacina@gmail.com
Sergey Bondarenko, PhD Student sergey.bondarenko@unimi.it
Ashish Dhyani, PhD Student ashishdhyani2010@gmail.com
Federica Sala, PhD Student federica.sala3@gmail.com
Sig.ra Patrizia Uboldi, Laboratory Technician patrizia.uboldi@unimi.it
Sig.ra Paola Marino, Personal Assistant segreteria.catapano@unimi.it

 

Research Interests

The research is focussed on the investigation of the correlation between lipids, lipoproteins and atherosclerosis via a traslatiponal approach which includes studies in vitro, and in vivo. The lab takes advantage of the long lasting collaboration with the SISA center for the Study of Atherosclerosis. The key areas where the lab is active are the following:

  • Link between lipoproteins and innate and adaptive immunity
  • Lipoproteins and endothelium: studies on endothelial function and gene expression
  • Molecular genetics of cardiovascular disease
  • Structure-Function relationship of human apoliproteins also using monoclonal antibodies isolation and characterisation of endothelial cell precursors from humans
  • Pathways modulating cholesterol efflux from cholesterol-laden cells.
  • The long pentraxin PTX3 and cardiometabolic disorders.
  • Innate and adaptive immunity in atherosclerosis
  • HDL and immunity

 

Techniques 

-       Biochemical and molecular biology techniques

-       Flow cytometry

-       Lipoproteins ultracentrifugation

-       Cardiovascualr Genetics and Genomics

 

Selected Publications 

Gene silencing approaches for the management of dyslipidaemia.
Norata GD, Tibolla G, Catapano AL.
Trends Pharmacol Sci. 2013 Apr;34(4):198-205.

Identification of seven loci affecting mean telomere length and their association with disease.
Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, Hottenga JJ, Fischer K, Esko T, Surakka I, Broer L, Nyholt DR, Mateo Leach I, Salo P, Hägg S, Matthews MK, Palmen J, Norata GD, O'Reilly PF, Saleheen D, Amin N, Balmforth AJ, Beekman M, de Boer RA, Böhringer S, Braund PS, Burton PR, de Craen AJ, Denniff M, Dong Y, Douroudis K, Dubinina E, Eriksson JG, Garlaschelli K, Guo D, Hartikainen AL, Henders AK, Houwing-Duistermaat JJ, Kananen L, Karssen LC, Kettunen J, Klopp N, Lagou V, van Leeuwen EM, Madden PA, Mägi R, Magnusson PK, Männistö S, McCarthy MI, Medland SE, Mihailov E, Montgomery GW, Oostra BA, Palotie A, Peters A, Pollard H, Pouta A, Prokopenko I, Ripatti S, Salomaa V, Suchiman HE, Valdes AM, Verweij N, Viñuela A, Wang X, Wichmann HE, Widen E, Willemsen G, Wright MJ, Xia K, Xiao X, van Veldhuisen DJ, Catapano AL, Tobin MD, Hall AS, Blakemore AI, van Gilst WH, Zhu H, Consortium C, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Talmud PJ, Pedersen NL, Perola M, Ouwehand W, Kaprio J, Martin NG, van Duijn CM, Hovatta I, Gieger C, Metspalu A, Boomsma DI, Jarvelin MR, Slagboom PE, Thompson JR, Spector TD, van der Harst P, Samani NJ.
Nat Genet. 2013 Apr;45(4):422-7, 427e1-2.

Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data.
Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen TP, Sander D, Plichart M, Catapano AL, Robertson CM, Kiechl S, Rundek T, Desvarieux M, Lind L, Schmid C, DasMahapatra P, Gao L, Ziegelbauer K, Bots ML, Thompson SG; PROG-IMT Study Group.
Lancet. 2012 Jun 2;379(9831):2053-62.

HDLs, immunity, and atherosclerosis.
Norata GD, Pirillo A, Catapano AL.
Curr Opin Lipidol. 2011 Oct;22(5):410-6.

ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).
European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman MJ, Durrington P, Erdine S, Halcox J, Hobbs R, Kjekshus J, Filardi PP, Riccardi G, Storey RF, Wood D; ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees.
Eur Heart J. 2011 Jul;32(14):1769-818 

Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.
Ammirati E, Cianflone D, Banfi M, Vecchio V, Palini A, De Metrio M, Marenzi G, Panciroli C, Tumminello G, Anzuini A, Palloshi A, Grigore L, Garlaschelli K, Tramontana S, Tavano D, Airoldi F, Manfredi AA, Catapano AL, Norata GD.
Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1832-41.

Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis.
Norata GD, Marchesi P, Pulakazhi Venu VK, Pasqualini F, Anselmo A, Moalli F, Pizzitola I, Garlanda C, Mantovani A, Catapano AL.
Circulation. 2009 Aug 25;120(8):699-708.

Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells.
Norata GD, Marchesi P, Pirillo A, Uboldi P, Chiesa G, Maina V, Garlanda C, Mantovani A, Catapano AL.
Arterioscler Thromb Vasc Biol. 2008 May;28(5):925-31.

Effects of fractalkine receptor variants on common carotid artery intima-media thickness.
Norata GD, Garlaschelli K, Ongari M, Raselli S, Grigore L, Catapano AL.
Stroke. 2006 Jun;37(6):1558-61.

High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells.
Norata GD, Callegari E, Marchesi M, Chiesa G, Eriksson P, Catapano AL.
Circulation. 2005 May 31;111(21):2805-11. 

 

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