Team - Laboratory of Pharmacology of Neurodegeneration
Phone +3902/50318265Manuela Mellone is a postdoctoral fellow at DISFEB. From 2007 to 2011 she was a PhD student at the Department of Clinical Neurosciences, University of Cambridge (UK), where she developed a novel in vitro system to model tauopathy. Her current research investigates the glutamatergic synapse, with a specific focus on NMDA receptors, to develop innovative pharmacological strategies for Parkinson’s disease and levodopa-induced dyskinesia.
Silvia graduated in Pharmacy in 2011 and in 2017 she obtained the PhD in Pharmacological Experimental and Clinical Sciences (University of Milan). In November 2017, she got a postdoc position funded by AIRALHZ to investigate the role of the Cyclase-Associated Protein 2 (CAP2) in the synapses and its involvement in Alzheimer Disease.
Phone +3902/50318265Laura D’Andrea obtained the PhD in Applied Biotechnology and translational medicine at the University of Rome Tor Vergata in 2018. Currently, she is a postdoctoral fellow at DISFEB and studies the contribution of synaptonuclear messengers to neurodevelopmental disorders, such as Fragile X syndrome.
My project focusses on unraveling the early stages of Alzheimer’s disease (AD) and to understand the role of CAP2 as the link between spine dysmorphogenesis and the amyloid cascade. ADAM10 is responsible for the α-secretase cleavage of APP, that prevents Aβ generation in AD. We recently identified an actin-binding protein named CAP2 as a novel protein binding partner of ADAM10. CAP2 is implicated in actin cytoskeleton remodelling and vesicle trafficking, and microarray analysis of AD patient hippocampi, revealed a decrease of CAP2, which makes it a promising target to investigate.
Nicolò Carrano is a PhD student ta the DISFEB. After graduating in Medical Biotechnology and Molecular Medicine, in 2016 he started the PhD in the lab of professor Di Luca and Professor Gardoni. His research project focuses on the study of the role of the synaptonuclear messenger RNF10 in synaptic plasticity and in neurodevelopment, in particular in the critical period for synaptogenesis.
Elena Ferrari is a PhD student at Disfeb from October 2018 under the supervision of prof. Fabrizio Gardoni. The main focus of her project is to investigate the role of the proteins rabphilin3a and alpha-synuclein in Parkinson’s disease’s synaptic dysfunction through different experimental approaches. In particular, she is also conducting studies at the Biophysics and computational biochemistry laboratory coordinated by prof. Ivano Eberini.
Phone +3902/50318265Luca Franchini graduated in Pharmacy and from October 2017 is PhD student in XXXIII° cycle “Pharmacological, experimental and clinical Sciences” at DISFEB. Under Monica Di Luca and Fabrizio Gardoni supervision, he investigates the modulation and role of Rabphilin3A-NMDAR protein complex at the postsynapse, during hippocampal synaptic plasticity and cognitive functions.